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We compared the distribution of characteristics between sildenafil users and nonusers, using t or χ2 tests. Person-years of follow-up were calculated from the return of the 2000 questionnaire to the date of diagnosis of melanoma or nonmelanoma skin cancer, death, the last questionnaire response, or January 2010, whichever came first. Cox proportional hazards analysis was performed to calculate hazard ratios (HRs) and 95% CIs. We evaluated sildenafil use at baseline (in the past 3 months, which was reported in 2000) as the main exposure. price cialis
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Non-arteritic anterior ischemic optic neuropathy (NAION), a cause of decreased vision including permanent loss of vision, has been reported rarely postmarketing in temporal association with the use of phosphodiesterase type 5 (PDE5) inhibitors, including Cialis. Most, but not all, of these patients had underlying anatomic or vascular risk factors for development of NAION, including but not necessarily limited to: low cup to disc ratio (“crowded disc”), age over 50, diabetes, hypertension, coronary artery disease, hyperlipidemia, and smoking. It is not possible to determine whether these events are related directly to the use of PDE5 inhibitors, to the patient's underlying vascular risk factors or anatomical defects, to a combination of these factors, or to other factors [see Warnings and Precautions (5.4)].In these 7 trials, Cialis was taken as needed, at doses ranging from 2.5 to 20 mg, up to once per day. Patients were free to choose the time interval between dose administration and the time of sexual attempts. Food and alcohol intake were not restricted.
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